Clostridium difficile PCR ribotype 027/PFGE type NAP1 – why is it emerging?
نویسندگان
چکیده
Department of Bacteriology, Swedish Institute for Infectious Disease Control, Solna; Department of Clinical Microbiology and Department of Infectious Diseases, Örebro University Hospital, Örebro; Department of Communicable Disease Control and Prevention, Karolinska University Hospital, Stockholm; Department of Clinical Sciences, Infectious Disease Research Unit, Malmö University Hospital, Lund University, Malmö,
منابع مشابه
Lack of association between clinical outcome of Clostridium difficile infections, strain type, and virulence-associated phenotypes.
Clostridium difficile strain NAP1/027 (North American pulsed-field gel electrophoresis [PFGE] type 1 and PCR ribotype 027 [R027]) has been associated with recent outbreaks in North America and Europe. It has been associated with more severe disease symptoms, higher mortality rates, and greater risk of relapse. This strain is thought to produce more toxins and sporulate to higher levels. However...
متن کاملUse of highly discriminatory fingerprinting to analyze clusters of Clostridium difficile infection cases due to epidemic ribotype 027 strains.
We compared multilocus variable-number tandem-repeat analysis (MLVA) and macrorestriction endonuclease analysis using pulsed-field gel electrophoresis (PFGE) to determine their utility to identify clusters of Clostridium difficile infection (CDI) among 91 isolates of PCR ribotype 027 (NAP1, for North American pulsed-field type 1) from nine hospitals (and 10 general practitioners associated with...
متن کاملFirst Report of Clostridium difficile NAP1/027 in a Mexican Hospital
BACKGROUND AND OBJECTIVE Clostridium difficile NAP1/ribotype 027 is associated with severe disease and high mortality rates. Our aim was to determine the prevalence of NAP1/ribotype 027 among C. difficile isolates in a tertiary care hospital, and review the main clinical data. METHODS We included 106 stool samples from 106 patients. Samples were tested for A&B toxins and were cultured on CCFA...
متن کاملToxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe.
BACKGROUND Toxins A and B are the primary virulence factors of Clostridium difficile. Since 2002, an epidemic of C difficile-associated disease with increased morbidity and mortality has been present in Quebec province, Canada. We characterised the dominant strain of this epidemic to determine whether it produces higher amounts of toxins A and B than those produced by non-epidemic strains. ME...
متن کاملA case of Clostridium difficile-associated disease due to the highly virulent clone of Clostridium difficile PCR ribotype 027, March 2007 in Germany.
Increasing rates of Clostridium difficile-associated disease (CDAD) have been reported from North America since 2003. This increase is associated with the emergence and spread of a particular strain of C. difficile characterised as PCR ribotype 027 or pulsotype NAP1. This epidemic strain produces toxins A and B and the binary toxin, is resistant to erythromycin and the newer fluoroquinolones, a...
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تاریخ انتشار 2008